Serotonin and the Mesenteric Circulation

1: 16). After the epidemic 89 (77%) had a four-fold titre rise. Of those under 20 years of age 46 out of 50 had posi,tive titres after the infection. Clinical illness occurred in over 50% of infected subjects. Five years later a follow-up study was done using 75-g oral carbohydrate load glucose tolerance test. Serum neutralizing antibody titres and two-hour plasma glucose levels were measured. Of the 136 persons under 25 years of age (M.= 65, F.= 71) the highest two-hour plasma glucose was 133 mg/100 ml. Persistence of positive titre levels was also documented since 77% of these subjects had a positive neutralizing antibody titre level. Even though it was in the young diabetic that Dr. Gamble and his colleagues were able to show the strongest association with positive Coxsackie B4 titres we could not show that Coxsackie B4 infection caused a single case of diabetes, though the attack rate in the 136 under 20 years of age at the time of the epidemic was extremely high. -We are, etc., STEPHEN E. DIPPE PETER H. BENNETT